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Lipoprotein(a)

High levels of the "bad" form of cholesterol known as lipoprotein (a) have been found to be an independent risk factor for heart disease and stroke. This form of "bad" cholesterol can be inherited and can be difficult to lower with diet alone. What's more important is that your other cholesterol numbers can be just fine, while the Lp(a) level is still very high. The only way to know is to have your blood level of Lp(a) checked.

An ideal lipoprotein (a) level is considered less than 30. Intermediate levels are between 30 and 60, and high levels are considered over 60. It's not known yet what causes a high Lp(a) level, but genetic factors may be most important. Lp(a) levels may rise after menopause in women. Levels are also increased by the "male" hormone testosterone (although women make testosterone, too - just less of it). Some reports suggest that soy supplementation may also boost Lp(a) levels.

Here's how to lower your level of lipoprotein (a):

  1. First, if your Lp(a) level is elevated, you should lower your LDL level as low as you can.
  2. Increase your vitamin C intake. We recommend Vitamin C ester - 500 mg to 2000 mg daily for people with high Lp(a).
  3. Increase your intake of vitamin B3, also known as niacin. High doses of niacin can cause a tremendous flushing and itching reaction of the skin.  Here are some ways to minimize the flushing associated with niacin:
    • Use the "non-flushing" form of niacin called inositol hexaniacinate
    • Take niacin with meals - on a full stomach
    • Start with a low dose (e.g. 500 mg) and increase slowly (e.g. by 500 mg every few days), until you either develop side effects (flushing, itching, stomach cramps or diarrhea) or you reach your target dosage. In this way it's possible to reach 2000 to 3000 mg per day without side effects.
    • If you are on niacin therapy to lower Lp(a) levels you should have your blood monitored every 3 months or so with lipid levels, liver enzymes and blood sugar (glucose) levels.