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Homocysteine

Homocysteine is now recognized as an independent and important risk factor in the following conditions:

  • Heart attack
  • Stroke
  • Alzheimer's disease
  • Atherosclerosis (hardening of the arteries)
  • Birth defects
  • Complications of pregnancy, e.g. toxemia

Homocysteine is one of the amino acids, which are the building blocks of proteins. Many factors may elevate homocysteine levels including genetic factors, diet, vitamin deficiencies, and certain medical conditions such as kidney disease. It is normally converted to other amino acids in a process that requires B vitamins such as B12, folic acid, and B6 (pyridoxine), as well as the nutrient betaine (trimethylglycine). B vitamin intake is important in reducing levels of homocysteine.

Optimal homocysteine levels are considered less than 9. Intermediate levels are between 9 and 12, and high levels over 12. We recommend the following vitamins:

  • Folic acid (also known as folate) 400 mcg to 1000 mcg daily
  • Vitamin B6 (also known as pyridoxine) 25 to 50 mg daily
  • Vitamin B12 100 to 1000 mcg daily

We also strongly recommend testing your homocysteine level.  People with elevated levels while taking adequate amounts of these vitamins will need higher levels of the vitamins, and the addition of trimethylglycine to control homocysteine levels.


 

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"Hyman and Liponis provide a provocative, practical, accessible, and highly readable guide to this important subject and challenge aspects of the traditional medical model."
Peter Libby M.D.